Carbon tetrabromide → HCID 54484537, compound

Participants

Reaction Conditions

Reaction Steps

3-(3-Diethoxyphosphoryl-4-hydroxymethyl-phenyl)propionic acid methyl ester (330 mg, 1 mmol), PPh3 (289 mg, 1.1 mmol) and CBr4 (365 mg, 1.1 mmol) were dissolved in 5 mL dry THF. The reaction mixture was stirred at 25° C. for 1 hr. The mixture turned cloudy. Solid was filtered and the filtrate was concentrated. The residue was further purified by flash column chromatography on silica gel (EtOAC/hexane 3/1, Rf=0.40). Pure product was obtained as an oil 150 mg (yield 38%).

Provenance & Evidence