反应详情

To a solution of 5-formyl-3-hydroxynaphtho[2,3-c]furan-1(3H)-one (190 mg, 0.83 mmol) pyridine (1.66 mL) at rt was added Ac2O (126 mg, 0.117 mL, 1.25 mmol). The solution was stirred at rt for 18 hours and then poured into brine and extracted with EtOAc. The extract was dried over MgSO4 and concentrated The crude material was chromatographed on silica get (3:1 hexanes:EtOAc) to give the title compound (100 mg, 44%).

1. extractionextracted with EtOAc
2. dry with materialThe extract was dried over MgSO4
3. concentrationconcentrated The crude material
4. customwas chromatographed on silica
5. customget (3:1 hexanes:EtOAc)