HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → HCID 11840927, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 6-Amino-1-hexanol | HCID 19960 | — |
| Reactant | Biotin | HCID 171548 | — |
| Reactant | Potassium Acetate | HCID 517044 | — |
| Reactant | HCID 178418287 | HCID 178418287 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 11840927 | HCID 11840927 | — |
Reaction Steps
Biotin is conjugated to 6-aminohexanol using dicyclohexyl carbodiimide reagent in DMF solvent. The resulting alcohol is oxidized to the aldehyde using pyridinium chlorochromate, potassium acetate in methylene chloride at room temperature (according to the procedure of Ducray et al., J. Org. Chem., 1999, 64:3800-3801). The aldehyde compound is purified by silica column chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06576752B1 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-c8113bfed0ad469891c694353bb5214a |
| Source note | uspto-grants-2003_06 |