Dichloromethane → HCID 86601561, compound

Participants

Reaction Steps

Into a 100 mL 1-neck round bottom flask, equipped with a magnetic stir bar and septurn under N2 was charged the crude product of Example 14 step c) (4.62 g, 19 mmol), dry CH2Cl2 (20 mL) and Et3N (5.62 mL, 40 mmol). To this solution was added tosyl chloride (4.76 g, 25 mmol). The resulting mixture was stirred at ambient temperature for 4 hours. Charged H2O (0.27 g, 15 mmol) and stirred vigorously for 4 hours. The reaction mixture was diluted with 80 mL EtOAc and 50 mL H2O and the aqueous layer was separated. To the organic layer was added 75 ml of a 5% aq. solution of KH2PO4. After mixing and separation of the layers, the aqueous layer was removed. The organic layer was washed with 50 mL of saturated NaHCO3 solution, dried over Na2SO4, filtered and concentrated in vacuo to a constant weight of 7.40 g of the desired product.

Provenance & Evidence