3-Aminopyridine → HCID 22598273, compound

Participants

Reaction Steps

The procedure of Example 1 is repeated using 1.95 g (12.5 mmol) of 1-oxyl-2,2,6,6-tetramethylpiperidine, 3.90 g (38 mmol) of tert-butyl nitrite, 7.6 mg (0.0125 mmol) of (S,S)-(+)-N,N-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminocobalt(II), 120 mL of pyridine and 2.35 g (25 mmol) of 3-aminopyridine at 70° C. The crude product obtained is purified by vacuum flash chromatography (heptane) to give 1.5 g of the title compound as a colorless oil in 50.8% yield. The structure is confirmed by 1Hnmr and mass spectrographic analyses.

Provenance & Evidence