HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1369369Generated: November 1, 2026
Dimethylformamide → 9-Phenyl-9H-carbazole-3-carbaldehyde
https://huagongshe.com/reaction/1369369
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 9-Phenylcarbazole | HCID 70851 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | 9-Phenyl-9H-carbazole-3-carbaldehyde | HCID 18515440 | — |
Reaction Steps
To 0.49 g of N-phenylcarbazole in 2 mL of dichloroethane is added 0.19 mL of phosphorus oxychloride and 0.5 mL of DMF. The resulting mixture is stirred at 40° C. overnight. After stirring, 1 mL of 1 M HCl is added. After 5 additional minutes, the mixture is diluted with 1 M HCl and extracted with ethyl acetate. The crude product is purified by column chromatography on silica gel to give 60 mg of Compound 7.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06579718B1 |
|---|
| Source dataset | uspto-grants-2003_06 |
|---|
| ORD ID | ord-4cca24318bbc4925bc21d2465003b4e1 |
|---|
| Source note | uspto-grants-2003_06 |
|---|
