反应详情

温度

2.5 °C

Thionyl chloride (1.2 ml) was added dropwise into a mixture of 1.41 g of 4-[6-amino-8-(3-fluorophenyl)-2-iodo-9H-9-purinyl]butanoic acid and 75 ml of methanol over 15 minutes during the mixture was stirred at 0-5° C. in a nitrogen stream. This was raised to room temperature and stirred for 45 minutes and the solvent was evaporated. The resulting residue was dissolved in ethyl acetate and then the solution was washed with a saturated aqueous solution of sodium bicarbonate twice and then with brine once. The organic layer was dried over anhydrous sodium sulfate and concentrated to give 1.45 g of the title compound. The yield was 100%.

1. temperatureThis was raised to room temperature
2. stirringstirred for 45 minutes
3. customthe solvent was evaporated
4. dissolutionThe resulting residue was dissolved in ethyl acetate
5. washthe solution was washed with a saturated aqueous solution of sodium bicarbonate twice
6. dry with materialThe organic layer was dried over anhydrous sodium sulfate
7. concentrationconcentrated