Hydrochloric Acid → HCID 9955128, compound

Participants

Reaction Steps

4-(4-Fluorophenyl)-5-(2-[1-(S)-phenylethyl]amino-4-pyrimidyl)-2-(4-ethoxy-carbonylpiperazin-1-yl)oxazole (130 mg; 0.251 mmol in CHCl3 (2.6 ml) is treated with trimethylsilyl iodide (0.113 ml; 0.83 mmol) at 60 C. After 3 h a second portion of trimethylsilyl iodide (0.113 ml; 0.83 mmol) is added and the reaction heated at 60 C for 21 h. 6 M HCl in 1-propanol (3 ml) is added to the reaction mixture, stirred until dissolution is complete and then poured on a saturated solution of Na2CO3.

Provenance & Evidence