(Iodomethyl)cyclopentane → HCID 22609911, compound

Participants

Reaction Steps

This compound was prepared using the procedure described in Example 27 Step c) with cyclopentylmethyl iodide used instead of neopentyl iodide and 3-(2-fluorophenyl)-7-iodo-6-(2-methyl-2H-1,2,4-triazol-3-ylmethoxy)-1,2,4-triazolo[4,3-b]pyridazine used instead of 7-bromo-3-(2-fluorophenyl)-6-(2-methyl-2H-1,2,4-triazol-3-ylmethoxy)-1,2,4-triazolo[4,3-b]pyridazine. Data for the title compound: m.p. 135-137° C.; 1H NMR (360 MHz, CDCl3) δ1.18-1.28 (2H, m), 1.36-1.74 (4H, m), 1.76-1.86 (2H, m), 2.16-2.28 (1H, m), 2.66 (2H. d, J=7 Hz), 3.84 (3H, s), 5.49 (2H, s), 7.25-7.30 (1H, m), 7.36 (1H, dd, J=7 and 7 Hz), 7.50-7.60 (1H, m), 7.82-7.86 (2H, m), 7.89 (1H, s); MS (ES+) m/e 382 [MH]+. Anal. Found C, 60.85; H, 5.38%. C21H22FN7O.0.4H2O requires C, 60.83; H, 5.54%.

Provenance & Evidence