Potassium Carbonate → 4-chloro-2-iodo O-crotyl phenol

HRID 1369475Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1369475
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([I:9])[CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:16](Br)[CH:17]=[CH:18][CH3:19]>CN(C=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:16][CH:17]=[CH:18][CH3:19])=[C:4]([I:9])[CH:3]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 1224142-Butene, 1-bromo-HCID 6202344-Chloro-2-iodophenol

Produkt 1

HCID 698740424-chloro-2-iodo O-crotyl phenolAusbeute 95,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a mixture of 4-chloro-2-iodo phenol (5.11 mmol, 1.3 g) in DMF (40 mL) and potassium carbonate (10 mmol, 1.4 g) was added crotyl bromide (10.2 mmol, 1.6 g) and the reaction mixture was stirred at room temperature for one hour. The reaction was quenched with H2O (100 mL) and extracted with EtOAc (2×50 mL). The EtOAc layer was collected, dried, filtered and the filtrate was evaporated to obtain 4-chloro-2-iodo O-crotyl phenol (94%, 1.5 g).

Aufarbeitung

  1. customThe reaction was quenched with H2O (100 mL)
  2. extractionextracted with EtOAc (2×50 mL)
  3. customThe EtOAc layer was collected
  4. customdried
  5. filtrationfiltered
  6. customthe filtrate was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-896cd8e67c7a44a5925aae8fcc3f9ff8
Quelldatensatz
uspto-grants-2003_06
Patentnummer
US06579879B2

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