2-Naphthoyl chloride → HCID 22291125, compound

HRID 1369516Notes

Reaction equation

HRID 1369516 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11](Cl)=[O:12].[NH2:14][C:15]1[CH:16]=[CH:17][C:18]([CH3:36])=[C:19]([NH:21][C:22](=[O:35])[C:23]2[CH:28]=[CH:27][C:26]([O:29][CH2:30][CH2:31][O:32][CH2:33][CH3:34])=[CH:25][CH:24]=2)[CH:20]=1>>[CH3:36][C:18]1[CH:17]=[CH:16][C:15]([NH:14][C:11]([C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH:1]=2)=[O:12])=[CH:20][C:19]=1[NH:21][C:22](=[O:35])[C:23]1[CH:28]=[CH:27][C:26]([O:29][CH2:30][CH2:31][O:32][CH2:33][CH3:34])=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 752462-Naphthoyl chlorideHCID 22291090HCID 22291090, compound

Product 1

HCID 22291125HCID 22291125, compoundYield 23%

Procedure

Using an analogous procedure to that described in Example 22, 2-naphthoyl chloride was reacted with N-(5-amino-2-methylphenyl)-4-(2-ethoxyethoxy)benzamide to give the title compound in 23% yield; Mass Spectrum: M+H 470.

Sources & evidence

ORD record
ord-f8250816e8174f3e97207bdb61a2888f
Source dataset
uspto-grants-2003_06
Patent number
US06579872B1

Reaction notes

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