Morpholine → HCID 22291049, compound

Participants

Reaction Conditions

Reaction Steps

Using an analogous procedure to that described in Example 67 except that the reaction mixture was heated to 105° C. for 16 hours rather than to 100° C. for 6 days, N-[5-(5-chloro-2-nitrobenzamido)-2-methylphenyl]-4-diethylaminomethylbenzamide was reacted with morpholine. The solid so obtained was dissolved in methylene chloride and the solution was washed with a saturated aqueous sodium bicarbonate solution. The organic solution was dried (MgSO4) and evaporated. There was thus obtained the title compound in 64% yield; NMR Spectrum: (DMSOd6) 0.98 (t, 6H), 2.2 (s, 3H), 2.4-2.6 (m, 4H), 3.4-3.5 (m, 4H), 3.6 (s, 2H), 3.7-3.8 (m, 4H), 7.0-7.1 (m, 2H), 7.2 (m, 1H), 7.4-7.5 (m, 2H), 7.7 (m, 1H), 7.9 (d, 2H), 8.05 (d, 1H), 9.85 (s, 1H), 10.38 (broad s, 1H); Mass Spectrum: M+H+546.

Provenance & Evidence