Dimethylformamide → [3S,4aR,6S,8aR]-Ethyl-6-((4-Ethoxycarbonyl-5-Methyl-1H-Imidazol-1-yl)Methyl)-2-(Methoxycarbonyl)-1,2,3,4,4a,5,6,7,8,8a-Decahydroisoquinoline-3-Carboxylate

Temperature

20 °C

Sodium hydride (0.24 g, 1.2 eq) was washed with hexanes (3×10 ml) and suspended in dry THF (10 ml). To this was added a solution of 0.848 g of ethyl 4-methyl-5-imidazolecarboxylate in THF (5 ml) dropwise. The reaction mixture was stirred at 20° C. for 1.5 h and DMF (10 ml) was added. To the resulting solution was slowly added a solution of 2.43 g of [3S,4aR,6S,8aR]-ethyl-6-((3-nitrophenylsulfonyloxy)methyl)-2-(methoxycarbonyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylate in THF (10 ml). The reaction was stirred at ambient temperature over night under N2. The reaction was quenched with saturated aqueous sodium bicarbonate. The resulting white solid was removed by filtration and the filtrate was extracted with ethyl acetate (3×10 ml). The combined organic extract was washed with brine, dried (MgSO4), filtered, and evaporated to a light brown oil. The crude product was chromatographed over silica gel eluting with ethyl acetate to give 1.09 g of the intermediate title compound: MS m/z: 456.3 (m++1);

1. stirringThe reaction was stirred at ambient temperature over night under N2
2. customThe reaction was quenched with saturated aqueous sodium bicarbonate
3. customThe resulting white solid was removed by filtration
4. extractionthe filtrate was extracted with ethyl acetate (3×10 ml)
5. extractionThe combined organic extract
6. washwas washed with brine
7. dry with materialdried (MgSO4)
8. filtrationfiltered
9. customevaporated to a light brown oil
10. customThe crude product was chromatographed over silica gel eluting with ethyl acetate

ORD record

ord-3b3ecb52523d40a8b14725a419047aed

Source dataset

uspto-grants-2003_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06579886B2