Hydrochloric Acid → HCID 20594303, compound

Participants

Reaction Steps

To a solution of 0.325 g of [3S,4aR,6S,8aR]-ethyl-6-((4-ethoxycarbonyl-5-methyl-1H-imidazol-1-yl)methyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylate in dry ethyl acetate (5 mL) at 20° C. was added 3.4 ml of a 1.0M solution of HCl in diethyl ether. The resulting precipitate was collected through filtration and vacuum dried at 50° C. to yield 0.214 g of the final title compound, [3S,4aR,6S,8aR]-ethyl-6-((4-ethoxycarbonyl-5-methyl-1H-imidazol-1-yl)methyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylate dihydrochloride: MS m/z: 378.3 (m++1-HCl); 1H NMR 400 MHz (CD3OD) δ 9.12 (s, 1 H), 4.44-4.38 (m, 2H), 4.27-4.22 (m, 2H), 4.16-4.09 (m, 3H), 3.38-3.32 (t, 1 H), 3.06 (br s, 2 H), 3.08-3.02 (dd, 1H), 2.62 (s, 3H), 2.17-2.02 (m, 2H), 1.98-1.90 (m, 3H), 1.74-1.64 (m, 2H), 1.63-1.59 (m, 1H), 1.46-1.33 (m, 5H), 1.31-1.25 (t, 3H), 1.23-1.08 (m, 1H).

Provenance & Evidence