Hydrochloric Acid → HCID 20594300, compound

Participants

Reaction Steps

[3S,4aR,6S,8aR]-Ethyl-6-((4,5-bis-ethoxycarbonyl-1H-imidazol-1-yl)methyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylate was dissolved in ethyl acetate (50 mL) and a solution of 1.86M hydrochloric acid in ethyl acetate (11.65 mL, 0.0217 mol) was added giving a sticky solid. The reaction mixture was concentrated to dryness. The residue was dissolved in dichloromethane (10 mL) and added dropwise to diethyl ether (150 mL) causing the precipitation of 5.09 g (47%) of [3S,4aR,6S,8aR]-Ethyl-6-((4,5-bis-ethoxycarbonyl-1H-imidazol-1-yl)methyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylate dihydrochloride; mp 99-101° C.

Provenance & Evidence