Methyl isothiocyanate → HCID 9902990, compound

Participants

Reaction Conditions

Reaction Steps

A solution of obtained amine from Example 263 (150 mg, 0.542 mmol) in 5 mL of pyridine was treated with methyl isothiocyanate (198 mg, 2.71 mmol). The solution heated to 100° C. under a nitrogen atmosphere for 5 days. All volatiles were removed under reduced pressure. The resulting product was purified by flash column chromatography on silica gel eluting with chloroformn/NH4OH, affording 110 mg (58.1%) of the title compound.

Provenance & Evidence