HCID 22312692, compound → HCID 131723830, compound

HRID 1369715Notes

Reaction equation

HRID 1369715 reaction equation
[OH:1][CH:2]([CH:6]1[CH2:10][CH2:9][CH2:8][CH2:7]1)[C:3]([OH:5])=O.[NH2:11][C@H:12]([C:14]([C:16]1([NH2:35])[N:22]=[C:21]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:20]2[CH:29]=[CH:30][CH:31]=[CH:32][C:19]=2[N:18]([CH3:33])[C:17]1=[O:34])=[O:15])[CH3:13]>>[CH:6]1([CH:2]([OH:1])[C:3]([NH:11][C@H:12]([C:14]([C:16]2([NH2:35])[N:22]=[C:21]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[C:20]3[CH:29]=[CH:30][CH:31]=[CH:32][C:19]=3[N:18]([CH3:33])[C:17]2=[O:34])=[O:15])[CH3:13])=[O:5])[CH2:10][CH2:9][CH2:8][CH2:7]1

Participants

3

Reactant 2

HCID 22312692HCID 22312692, compoundHCID 53952692HCID 53952692, compound

Product 1

HCID 131723830HCID 131723830, compound

Procedure

Following General Procedure D above using (±)-α-hydroxy-cyclopentylacetic acid (Example P) and 3-(L-alaninyl)-amino-2,3-dihydro-1-methyl-5-1H-1,4-benzodiazepin-2-one (Example 8-B), the title compound was prepared as a white solid.

Sources & evidence

ORD record
ord-f5add347ff5e470c9b874fda2e8d816b
Source dataset
uspto-grants-2003_06
Patent number
US06579867B2

Reaction notes

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