HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-fluorobenzonitrile → n-(3-Chloro-4-cyanophenyl)alanine iso-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-fluorobenzonitrile | HCID 109000 | — |
| Reactant | 2-Methylpropyl 2-aminopropanoate hydrochloride | HCID 86200109 | — |
| Product | n-(3-Chloro-4-cyanophenyl)alanine iso-butyl ester | HCID 53791223 | — |
Reaction Steps
Following General Procedure AP above and using 2-chloro4-fluorobenzonitrile (Aldrich) and D,L-alanine iso-butyl ester hydrochloride (from Example AA above), the title compound was prepared. The product was recovered by column chromatography on silica gel using 1:5 EtOAc/hexanes as the eluant.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06579867B2 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-6b8532f5e73a4fe09dedd6710252ac79 |
| Source note | uspto-grants-2003_06 |