3,4-Dichlorophenylacetic acid → 2-[(3,4Dichlorophenyl)acetamido]butyric acid isobutyl ester

HRID 1369805Notes

Reaction equation

HRID 1369805 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[CH:6][C:7]=1[Cl:8].[NH2:13][CH:14]([CH2:22][CH3:23])[C:15]([O:17][CH2:18][CH:19]([CH3:21])[CH3:20])=[O:16]>>[CH2:18]([O:17][C:15](=[O:16])[CH:14]([NH:13][C:10](=[O:12])[CH2:9][C:4]1[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=1)[CH2:22][CH3:23])[CH:19]([CH3:20])[CH3:21]

Participants

3

Reactant 2

HCID 798743,4-Dichlorophenylacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 543898612-[(3,4Dichlorophenyl)acetamido]butyric acid isobutyl ester

Procedure

Following General Procedure BI above and using 3,4-dichlorophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above) the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Sources & evidence

ORD record
ord-5a7b61eb7b2b4fb995d0ad5ae1ce9760
Source dataset
uspto-grants-2003_06
Patent number
US06579867B2

Reaction notes

Loading…