2-Naphthaleneacetic acid → 2-[(2-naphthyl)acetamido]butyric Acid Iso-butyl Ester

HRID 1369812Notes

Reaction equation

HRID 1369812 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][C:12]([OH:14])=O.[NH2:15][CH:16]([CH2:24][CH3:25])[C:17]([O:19][CH2:20][CH:21]([CH3:23])[CH3:22])=[O:18]>>[CH2:20]([O:19][C:17](=[O:18])[CH:16]([NH:15][C:12](=[O:14])[CH2:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1)[CH2:24][CH3:25])[CH:21]([CH3:22])[CH3:23]

Participants

3

Reactant 2

HCID 113932-Naphthaleneacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 536358212-[(2-naphthyl)acetamido]butyric Acid Iso-butyl Ester

Procedure

Following General Procedure BI above and using 2-naphthylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-761bd8903be94dd5858af8f637be41ef
Source dataset
uspto-grants-2003_06
Patent number
US06579867B2

Reaction notes

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