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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1369832Generated: October 30, 2026

3,5-Difluorophenylacetic acid → N-[(3,5-difluorophenyl)acetyl]alanine iso-butyl ester

https://huagongshe.com/reaction/1369832

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-Difluorophenylacetic acidHCID 145424—
Reactant2-methylpropyl (2S)-2-aminopropanoateHCID 13743556—
ProductN-[(3,5-difluorophenyl)acetyl]alanine iso-butyl esterHCID 22894975—

Reaction Steps

Following General Procedure BI above, and using 3,5-difluorophenylacetic acid (Aldrich) and alanine iso-butyl ester (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06579867B2
Source datasetuspto-grants-2003_06
ORD IDord-2979412898c4405f90e9b60be6d2e991
Source noteuspto-grants-2003_06