3-Nitrophenylacetic acid → N-[(3-nitrophenyl)acetyl]methionine Ethyl Ester

HRID 1369837Notes

Reaction equation

HRID 1369837 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][C:11]([OH:13])=O)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].Cl.[CH2:15]([O:17][C:18](=[O:25])[C@H:19]([CH2:21][CH2:22][S:23][CH3:24])[NH2:20])[CH3:16]>>[CH2:15]([O:17][C:18](=[O:25])[C@H:19]([CH2:21][CH2:22][S:23][CH3:24])[NH:20][C:11](=[O:13])[CH2:10][C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)[CH3:16]

Participants

3

Reactant 2

HCID 158763-Nitrophenylacetic acidHCID 3083785Ethyl L-methionate hydrochloride

Product 1

HCID 53910855N-[(3-nitrophenyl)acetyl]methionine Ethyl Ester

Procedure

Following General Procedure BG above and using 3-nitrophenylacetic acid (Aldrich) and methionine ethyl ester hydrochloride (Aldrich), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by recrystallization from butyl chloride.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. customwas by recrystallization from butyl chloride

Sources & evidence

ORD record
ord-6ae85ea797ae4f8892fe522c5238a25f
Source dataset
uspto-grants-2003_06
Patent number
US06579867B2

Reaction notes

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