2-(Dimethylamino)ethanol → N-[(3-chlorophenyl)acetyl]alanine 2(N,N-dimethylamino)ethyl ester
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([NH:11][C@H:12]([C:14]([OH:16])=[O:15])[CH3:13])=[O:10])[CH:5]=[CH:6][CH:7]=1.[CH3:17][N:18]([CH2:20][CH2:21]O)[CH3:19]>>[CH3:17][N:18]([CH2:20][CH2:21][O:15][C:14](=[O:16])[C@H:12]([CH3:13])[NH:11][C:9](=[O:10])[CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=1)[CH3:19]Participants
3
Procedure
Following General Procedure BC above, and using N-(3-chlorophenyl-acetyl)alanine (from Example BD above) and 2-(N,N-dimethylamino) ethanol (Aldrich), the title compound can be prepared. The reaction was monitored by tlc on silica gel and purification was by liquid chromatography using 0.1:2:0.79 NH4OH:EtOH:CHCl3 as the eluant.
Sources & evidence
- ORD record
- ord-58c6811cf0f843e698fff9ac2ced3a62
- Source dataset
- uspto-grants-2003_06
- Patent number
- US06579867B2
Reaction notes
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