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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1369863Generated: October 31, 2026

Methyl 2-(2-nitro-4-(trifluoromethyl)phenyl)acetate → 6-Trifluoromethyloxindole

https://huagongshe.com/reaction/1369863

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 2-(2-nitro-4-(trifluoromethyl)phenyl)acetateHCID 83569—
CatalystPalladiumHCID 23938—
Product6-TrifluoromethyloxindoleHCID 608487—

Reaction Steps

Methyl 2-nitro-4-trifluoromethylphenylacetate (26 mg) was hydrogenated over 10% palladium on carbon and then heated at 100 OC for 3 hours. The catalyst was removed by filtration and the solvent evaporated to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06579897B2
Source datasetuspto-grants-2003_06
ORD IDord-303127efce414a8281ffe3ee2036a64c
Source noteuspto-grants-2003_06