Dimethyl 3'-ethoxy-3-nitrobiphenyl-4-malonate → 3'-Ethoxy-3-nitrobiphenyl-4-acetic acid

Participants

Reaction Steps

Crude dimethyl 3′-ethoxy-3-nitrobiphenyl-4-malonate was heated at 100° C. in 60 mL of 6N hydrochloric acid for 4 days and then cooled. The precipitate was collected by filtration, washed with water and hexane, and dried to give 4.7 g of crude 3′-ethoxy-3-nitrobiphenyl-4-acetic acid as a light tan solid.

Provenance & Evidence