Trifluoroacetic acid → HCID 11206513, compound

Participants

Reaction Steps

A solution of 350 mg (1.1 mmol) of 5-tert-butoxycarbonyl-3a-fluoro-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one in 5 mL of dichloromethane is mixed with 5 ml of trifluoroacetic acid at room temperature. After 1 hour, the batch is diluted with water (100 ml) and ethyl acetate (100 ml). The organic phase is separated, washed with water (50 ml), saturated NaHCO3, (2×50 ml) and saturated NaCl (50 ml), dried (Na2SO4) and concentrated by evaporation in a vacuum. Column chromatography of the residue on silica gel with hexane-ethyl acetate yields 160 mg of product.

Provenance & Evidence