Lawesson's reagent → HCID 11333516, compound

Participants

Reaction Steps

A solution of 150 mg (0.73 mmol) of 3a-fluoro-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one in 50 ml of THF is mixed with 607 mg (1.5 mmol) of Lawesson's reagent. After 1 hour of stirring at room temperature, the batch is refluxed for 2 hours. Then, the reaction mixture is concentrated by evaporation and the residue is purified by column chromatography on silica gel (eluant: hexane-ethyl acetate): 150 mg of product.

Provenance & Evidence