Ammonia → HCID 9859088, compound

HRID 1369909Notes

Reaction equation

HRID 1369909 reaction equation
[F:1][C:2]12[CH2:14][CH2:13][CH2:12][CH:11]1[C:10]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:4][C:3]2=S.[NH3:16]>>[NH2:16][C:3]1[C:2]2([F:1])[CH2:14][CH2:13][CH2:12][CH:11]2[C:10]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[N:4]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 11333516HCID 11333516, compound

Product 1

HCID 9859088HCID 9859088, compound

Procedure

142 mg (0.64 mmol) of 3a-fluoro-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinoline-4-thione is dissolved in 50 ml of 7 M methanolic ammonia solution. After 1 hour of stirring at room temperature, the batch is concentrated by evaporation in a vacuum, and the residue is purified by column chromatography on silica gel with dichloromethane-ethanol as an eluant: 108 mg of product, melting point 174-6° C.

Workup

  1. concentrationthe batch is concentrated by evaporation in a vacuum
  2. customthe residue is purified by column chromatography on silica gel with dichloromethane-ethanol as an eluant

Sources & evidence

ORD record
ord-cd044c67a8cc48b9a0c05f8fa8528895
Source dataset
uspto-grants-2003_06
Patent number
US06579883B1

Reaction notes

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