Lawesson's reagent → HCID 18516393, compound

Participants

Reaction Steps

A solution of 0.83 g (3.5 mmol) of 8-chloro-3a-fluoro-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one in 100 ml of THF is refluxed with 2.86 g (7.1 mmol) of Lawesson's reagent for 1.5 hours. Then, the reaction mixture is concentrated by evaporation, and the residue is purified by column chromatography on silica gel with hexane-ethyl acetate: 0.86 g of product.

Provenance & Evidence