Ammonia → HCID 9794725, compound

Participants

Reaction Steps

90 mg (0.35 mmol) of 8-chloro-3a-fluoro-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinoline-4-thione is dissolved in 20 ml of 7 M methanolic ammonia solution. After 2 hours of stirring at room temperature, the batch is concentrated by evaporation in a vacuum, and the residue is purified by column chromatography on silica gel with ethyl acetate: 73 mg of product, melting point 223° C.

Provenance & Evidence