Imidazole → HCID 18516372, compound

Participants

Reaction Steps

At 0° C., 0.62 g (5.4 mmol) of tert-butyldimethylsilyl chloride and 0.72 g (10.7 mol) of imidazole are added to a solution of 0.62 g (2.7 mmol) of 7-(2-hydroxyethyl)-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one in 10 ml of DMF. After 4 hours at room temperature, the batch is diluted with ether, washed with water, 10% citric acid and saturated NaHCO3, dried (Na2SO4) and concentrated by evaporation in a vacuum. Column chromatography with hexane-ethyl acetate on silica gel yields 0.79 g of product.

Provenance & Evidence