HCID 18516383, compound → HCID 18516380, compound

Participants

Reaction Steps

0.77 g (1.7 mmol) of 5-tert-butyloxycarbonyl-7-[2-(tert-butyldimethylsilyloxy)ethyl]-3a-fluoro-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one is stirred in 10 ml of 4 M hydrochloric acidic dioxane for 2 hours at room temperature. The batch is concentrated by evaporation in a vacuum, the residue is taken up in ethyl acetate, washed with saturated NaHCO3, dried (Na2SO4) and concentrated by evaporation in a vacuum. Column chromatography on silica gel with hexane-ethyl acetate yields 0.26 g of product.

Provenance & Evidence