Methyl Acrylate → HCID 69653027, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 528 mg (2.0 mmol) of 7-bromo-1,2,3,5-tetrahydrocyclopenta[c]quinolin-4-one (WO 99/41240), 0.36 ml (4.0 mmol) of acrylic acid methyl ester, 116 mg (0.1 mmol) of tetrakis(triphenylphosphine)palladium and 0.56 ml (4.0 mmol) of triethylamine in 25 ml of DMF is stirred for 3 hours at 120° C. The batch is diluted with ethyl acetate, washed with water, dried (Na2SO4) and concentrated by evaporation in a vacuum. Purification of the residue on silica gel with dichloromethane-ethanol yields 550 mg of product.

Provenance & Evidence