Sulfuric Acid → HCID 69680015, compound

Participants

Reaction Steps

A solution of 4.0 g (14.6 mmol) of 7-(2-methoxycarbonylethyl)-1,2,3,3a,5,9b-hexahydro-cyclopenta[c]quinolin-4-one in 60 ml of THF and 100 ml of methanol is stirred for 24 hours with 29 ml of 1 M aqueous sodium hydroxide solution. The batch is set at pH 5 with 10% sulfuric acid and extracted with dichloromethane and ethyl acetate. The combined extracts are freeze-dried (Na2SO4) and concentrated by evaporation in a vacuum. After column chromatography on silica gel with dichloromethane-methanol, 3.4 g of 7-(carboxyethyl)-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one is isolated.

Provenance & Evidence