Ammonia → HCID 10839443, compound

Participants

Reaction Steps

6-Chloro-9-(5-O-trityl-3-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9-H-purine (3.15 g, 4.98 mmol) was dissolved in 100 ml methanolic ammonia (saturated at 0° C.) and left in a sealed tube at 100° C. for 2 days. After cooling, the solvent was carefully distilled off, and the residues were dissolved in 100 ml chloroform. The insolubles were filtered off and the solution was applied to a silica gel column (3.5×50 cm) and eluted with 3 to 10% ethanol/methylene chloride solution (4000 ml). Product fractions were collected, and the solution was concentrated to give white crystals (1.87 g, 3.66 mmol, 73%)

Provenance & Evidence