6-[(4-Chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-1-cyclopropylmethyl-4-(3-ethynyl-phenyl)-1H-quinolin-2-one → 3-methyl-3H-imidazol 4-cyclopropylmethyl-4-(3-ethynyl-phenyl)-1H-quinolin-2-one

Participants

Reaction Steps

The same procedure that was used in example 3 was followed except 6-[(4-Chloro-phenyl) -hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-1-cyclopropylmethyl-4-(3-ethynyl-phenyl)-1H-quinolin-2-one (1.80 g, 3.5 mmol) was used in place of 6-[(4-Chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl-4-(3-ethynyl-phenyl)-1-methyl-1H-quinolin-2-one to give 6-[Amino(4chloro-phenyl)-(3-methyl-3H-imidazol-4-cyclopropylmethyl-4-(3-ethynyl-phenyl)-1H-quinolin-2-one (1.12 g, 62%) as a yellow foam.

Provenance & Evidence