HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-Amino-4-phenylpyrimidine-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Carbonic acid-guanidine (1:1) | HCID 286947 | — |
| Reactant | 2-[(Dimethylamino)methylene]-3-oxo-3-phenylpropanenitrile | HCID 3845590 | — |
| Product | 2-Amino-4-phenylpyrimidine-5-carbonitrile | HCID 723688 | — |
Reaction Steps
2-Amino-5-cyano-4-phenylpyrimidine was prepared from guanidine carbonate (1.57 g, 17.5 mmol), 1-phenyl-2-cyano-3-dimethylaminopropen-1-one (3.5 g, 17.5 mmol) and sodium hydroxide (720 mg, 19.3 mmol) in a similar method to the compound of Example 1, as an off-white solid, m.p. 147°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06579983B1 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-16b657bd1a3b431baadcd57bb19135fc |
| Source note | uspto-grants-2003_06 |