反应详情

温度

45 °C

Fuming nitric acid(10.4 ml) was added dropwise to a mixture of 6-hydroxynicotinic acid (15 g) and concentrated sulfuric acid(45 ml) at 0° C. The reaction mixture was slowly heated to 45° C. and maintained at the same temperature for 3 hours. The mixture was poured into ice-water, and the resultant precipitate was collected by suction filtration, washed with water, and air-dried to give 6-hydroxy-5-nitronicotinic acid (8.63 g) as a pale yellow solid.

1. temperaturemaintained at the same temperature for 3 hours
2. filtrationthe resultant precipitate was collected by suction filtration
3. washwashed with water
4. customair-dried