Nitric Acid → HCID 178524776, compound

HRID 1370125Notes

Reaction equation

HRID 1370125 reaction equation
[N+:1]([O-:4])(O)=[O:2].[OH:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([OH:12])=[O:11])=[CH:8][N:7]=1.S(=O)(=O)(O)O>>[OH:5][C:6]1[C:14]([N+:1]([O-:4])=[O:2])=[CH:13][C:9]([C:10]([OH:12])=[O:11])=[CH:8][N:7]=1

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 178418479HCID 178418479, compound

Product 1

HCID 178524776HCID 178524776, compound

Conditions

Temperature
45 °C

Procedure

Fuming nitric acid(10.4 ml) was added dropwise to a mixture of 6-hydroxynicotinic acid (15 g) and concentrated sulfuric acid(45 ml) at 0° C. The reaction mixture was slowly heated to 45° C. and maintained at the same temperature for 3 hours. The mixture was poured into ice-water, and the resultant precipitate was collected by suction filtration, washed with water, and air-dried to give 6-hydroxy-5-nitronicotinic acid (8.63 g) as a pale yellow solid.

Workup

  1. temperaturemaintained at the same temperature for 3 hours
  2. filtrationthe resultant precipitate was collected by suction filtration
  3. washwashed with water
  4. customair-dried

Sources & evidence

ORD record
ord-51b5741cce2943fb8c62164aa30be5cb
Source dataset
uspto-grants-2003_06
Patent number
US06582351B1

Reaction notes

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