Phosphorus pentachloride → 4-Chloro-3-nitropyridine

Participants

Reaction Steps

5 g of 4-hydroxy-3-nitropyridine and 15.5 g of phosphorous pentachloride were added to 100 ml of dichloroethane and reacted under reflux for 90 minutes. When it was poured onto ice to separate an organic phase and allowed to stand at room temperature for a while, crystals were precipitated. They were collected by filtration and washed with hexane, to give 4.3 g of the title compound.

Provenance & Evidence