反应详情

Hydrogenate a mixture of 3-(1-ethyl-5-fluoro-indan-1-yl)-1-methyl-7-nitro-1H-indole (0.26 g, 0.77 mmol) and 5% palladium on carbon (26 mg) in ethanol (50 ml) at 60 psi at room temperature overnight. Filter catalyst and concentrate under high vacuum to obtain the title compound as oil (0.17 g, 71%). NMR (400 MHz, CDCl3): δ 0.83 (t, 3H), 2.05 (m, 1H), 2.25 (m, 2H), 2.60 (m, 1H), 2.96 (m, 2H), 3.72 (broad s, 2H, NH2), 4.02 (s, 3H), 6.43 (m, 2H), 6.76 (d, 2H), 6.83 (t, 1H), 6.97 (d, 1H), 7.02 (m, 1H).

1. concentrationFilter catalyst and concentrate under high vacuum