HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → HCID 54006895, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | N-tosyl-(s)-proline monohydrate | HCID 69463844 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | HCID 54006895 | HCID 54006895 | — |
Reaction Steps
N-(Toluene-4-sulfonyl)-L-proline hydrate was coupled to L-5-(1,1-dimethylethyl)-glutamic acid methyl ester hydrochloride using the procedure described in Method 3. The methyl ester was hydrolyzed using LiOH in THF/water to provide a solid, mp=164-166° C. The title compound was prepared, via cleavage of the t-butyl ester using trifluoroacetic acid in CH2Cl2, as a solid, mp=>200° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06583139B1 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-1002b7faaa594d98bbf244b0ef7bf809 |
| Source note | uspto-grants-2003_06 |