Dimethylformamide → HCID 131723928, compound

Participants

Reaction Steps

Camphorsultam (3 g, 14 mmole) in DMF (25 mol) was mixed with NaH (1.1 equiv.) for 15 minutes, then tert-butyl bromoacetate (2.5 ml) was added and the reaction mixture was stirred overnight. The solvent was evaporated to dryness and the residue was partitioned between aq-citric acid and EtoAc. The organic layer was washed with sat. aq. NaHCO3, and water, dried and evaporated to give the ester. (3.5 g)

Provenance & Evidence