Lithium Hydroxide → HCID 54503116, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-(4-methanesulfonylamino-phenyl)-2-{[1-(toluene-4-sulfonyl)-pyrrolidine-2-carbonyl]-amino}-propionic acid methyl ester (0.250 g, 0.477 mmol) in THF (1.0 mL) was added 1H LiOH (955 mL, 0.955 mmol) and the clear solution was stirred at 25° C., under nitrogen, for 16 h. The reaction solution was then diluted with additional water (50 mL) and washed with diethyl ether (25 mL). The aqueous layer was lyophilized to afford a fluffy white solid (0.216 g, 87%). MS (=ESI): 508 [M−1]−

Provenance & Evidence