HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → HCID 18510734, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Reactant | HCID 18510670 | HCID 18510670 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 18510734 | HCID 18510734 | 117.7% |
Reaction Steps
) PCl5 (0.027 mol) was added to a solution of (±)-N-[4-(cyanohydroxyphenylmethyl) phenyl]-4,5-dihydro-3-(3-pyridinyl)-5-isoxazolecarboxamide (0.023 mol) in THF (50 ml). The reaction mixture was stirred and refluxed for 2 hours. Et2O was added and the precipitate was filtered off and dried, yielding 7.2 g (80%) of (±)-N-[4-(chlorocyanophenylmethyl)phenyl]-4,5-dihydro-3-(3-pyridinyl)-5-isoxazolecarboxamide monohydrochloride (compound 496).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06583141B1 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-432bfdfdb6fb44d1a979968e088eba16 |
| Source note | uspto-grants-2003_06 |