Chloroacetyl chloride → HCID 18510991, compound

Participants

Reaction Conditions

Reaction Steps

Chloroacetyl chloride (0.55 g, 4.85 mmol) was added to a solution of [4-[4-(1,1-dimethylethyl)phenyl]-5-(4-pyridyl)-1,3-thiazol-2-yl]amine (1.0 g, 3.23 mmol) in N,N-dimethylacetaminde (10 mL) and the mixture was stirred at 60° C. for 14 hours. The solvent was concentrated under reduced pressure and the resultant residue was washed with ether and dried. The crude crystals obtained was recrystallized from ethanol to obtain the title compound (0.94 g, yield 69%).

Provenance & Evidence