Trifluoroacetic acid → Benzo(b)pyrido(4,3,2-de)(1,7)phenanthrolin-8-one

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Reaction Steps

30 mg (0.0756 mmol) of the compound of Example 4 and 1 mL of trifluoroacetic acid in 2 mL of CH2Cl2 are refluxed for 3 hours. After evaporating off the solvent on a rotary evaporator, the residue is taken up in 2 mL of 1N NaOH and 2 mL of CHCl3 and the mixture is stirred overnight. After recovering the organic phase, the aqueous phase is extracted with CHCl3 (5 times 10 mL). After drying the organic phases over MgSO4 and evaporating off the solvent on a rotary evaporator, 17 mg of compound are obtained in the form of yellow-colored crystals.

Provenance & Evidence