HCID 18511427, compound → HCID 18511415, compound

Participants

Reaction Steps

A solution of 1-benzyl-4-(2,8-bis(trifluoromethyl)-4-quinolinyl)-4-piperidinol (480 mg, 1.06 mmol) and palladium hydroxide (100 mg) in MeOH (25 mL) was stirred vigorously under an atmosphere of hydrogen (using balloons) for 3 h, filtered through a pad of celite and concentrated in vacuo. The resulting viscous syrup was triturated with ether to give the title compound (241 mg, 63%) as a pale-grey solid: mp 210-220° C. (dec); IR νmax (Nujol)/cm−1 3406, 2924, 1458, 1313, 1154 and 823; NMR δH (400 MHz, DMSO-d6) 1.89 (2H, d, J 13.1 Hz), 2.11-2.19 (2H, m), 2.85 (2H, br d, J 10.0 Hz), 3.05-3.10 (2H, m), 5.73 (1H, s), 7.90 (1H, t, J 8.6 Hz), 8.03 (1H, s), 8.34 (1H, d, J 7.0 Hz) and 9.34 (1H, d, J 8.3 Hz).

Provenance & Evidence