Boron tribromide → HCID 22396867, compound

Participants

Reaction Steps

A 0° C. solution of 3-benzoyl-10-(2-methoxyphenyl)-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole (936 mg, 2.36 mmol) in CH2Cl2 (20 mL) was treated with BBr3 (0.75 mL, 7.94 mmol). The reaction was stirred at room temperature under nitrogen for 16.5 hours. The reaction was cooled to 0° C. and slowly quenched with saturated NH4Cl solution. After stirring at room temperature for 1.7 hours the reaction was extracted with CH2Cl2. The organic layer was dried over MgSO4 and concentrated in vacuo to give 792 mg (88%) of a yellow foam as the title compound: MS m/z 383.3 (M++H).

Provenance & Evidence