HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 18511549, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3,4,5-Trichloronitrobenzene | HCID 88365 | — |
| Reactant | HCID 18511537 | HCID 18511537 | — |
| Product | HCID 18511549 | HCID 18511549 | — |
Reaction Steps
3-(2,6-Dichloro-4-nitro-benzyl)-isoquinoline was synthesized (79%) from isoquinolin-3-yl-acetonitrile (234, 1.22 g, 7.26 mmol), 3,4,5-trichloronitrobenzene (Acros, 1.64 g, 7.26 mmol) and NaH (Aldrich, 640 mg, 60%, 16.0 mmol) in a similar manner in two steps as described in Example 222.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06583157B2 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-ca0b86ca7307409a9941c87e0e6accfd |
| Source note | uspto-grants-2003_06 |