Benzoyl chloride → 6-[4-(Benzoyl)piperazin-1-yl]-2-cyclohexyl-2,3-dihydro-1H-isoindol-1-one

HRID 1370543Notes

Reaction equation

HRID 1370543 reaction equation
[CH:1]1([N:7]2[CH2:15][C:14]3[C:9](=[CH:10][C:11]([N:16]4[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]4)=[CH:12][CH:13]=3)[C:8]2=[O:22])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:23](Cl)(=[O:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[C:23]([N:19]1[CH2:18][CH2:17][N:16]([C:11]2[CH:10]=[C:9]3[C:14]([CH2:15][N:7]([CH:1]4[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]4)[C:8]3=[O:22])=[CH:13][CH:12]=2)[CH2:21][CH2:20]1)(=[O:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 7412Benzoyl chlorideHCID 22180413HCID 22180413, compound

Product 1

HCID 185108456-[4-(Benzoyl)piperazin-1-yl]-2-cyclohexyl-2,3-dihydro-1H-isoindol-1-one

Procedure

In the same manner as in Example 28, the title compound was prepared from the compound obtained in step (e) of Example 1 and benzoyl chloride.

Sources & evidence

ORD record
ord-15fee3ed0faa4770b87abfebb7d51e23
Source dataset
uspto-grants-2003_06
Patent number
US06583144B2

Reaction notes

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